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Protein conformational diversity correlates with evolutionary rate
(Oxford University Press, 2013-04)
Native state of proteins is better represented by an ensemble of conformers in equilibrium than by only one structure. The extension of structural differences between conformers characterizes the conformational diversity ...
Disorder transitions and conformational diversity cooperatively modulate biological function in proteins
(Wiley Blackwell Publishing, Inc, 2016-04)
Structural differences between conformers sustain protein biological function. Here, we studied in a large dataset of 745 intrinsically disordered proteins, how ordered-disordered transitions modulate structural differences ...
Protein conformational diversity modulates sequence divergence
(Oxford University Press, 2012-03)
It is well established that the conservation of protein structure during evolution constrains sequence divergence. The conservation of certain physicochemical environments to preserve protein folds and then the biological ...
Conformational diversity and the emergence of sequence signatures during evolution
(Current Biology, 2015-03)
Proteins' native structure is an ensemble of conformers in equilibrium, including all their respective functional states and intermediates. The induced-fit first and the pre-equilibrium theories later, described how ...
Evolutionary Conserved Positions Define Protein Conformational Diversity
(Public Library of Science, 2016-03)
Conformational diversity of the native state plays a central role in modulating protein function. The selection paradigm sustains that different ligands shift the conformational equilibrium through their binding to ...
CoDNaS: a database of conformational diversity in the native state of proteins
(Oxford University Press, 2013-10)
Motivation: Conformational diversity is a key concept in the understanding of different issues related with protein function such as the study of catalytic processes in enzymes, protein-protein recognition, protein evolution ...
Exploring Protein Conformational Diversity
(Springer, 2019)
The native state of proteins is composed of conformers in dynamical equilibrium. In this chapter, different issues related to conformational diversity are explored using a curated and experimentally based database called ...
Large scale analysis of protein conformational transitions from aqueous to non-aqueous media
(BioMed Central, 2018-01)
Background: Biocatalysis in organic solvents is nowadays a common practice with a large potential in Biotechnology. Several studies report that proteins which are co-crystallized or soaked in organic solvents preserve their ...
CoDNaS-RNA: a database of Conformational Diversity in the Native State of RNA
(Cold Spring Harbor Laboratory, 2020-10)
Conformational changes in RNA native ensembles are central to fulfill many of their biological roles. Systematic knowledge of the extent and possible modulators of this conformational diversity is desirable to better ...
CoDNaS 2.0: a comprehensive database of protein conformational diversity in the native state
(Oxford Journal, 2016-03)
CoDNaS (conformational diversity of the native state) is a protein conformational diversitydatabase. Conformational diversity describes structural differences between conformersthat define the native state of proteins. It ...